GeneTex中国官方网站
  • China

PD1抗体 [NAT105]

Anti-PD1 antibody [NAT105] used in IHC (Paraffin sections) (IHC-P). GTX20256

目录号 GTX20256

文献引用 25

宿主

 Mouse

克隆

 Monoclonal

克隆编号

 NAT105

同种型

 IgG1

实验应用

 WB, ICC/IF, IHC-P, IHC-Fr, FACS, IP, IHC

种属反应

 Human, Mouse
产品包装
500 μl (¥6400)
查看所有 PD1 的产品

产品应用

应用说明

*最佳稀释倍数与浓度应由研究人员确认
实验应用 稀释倍数
WB Assay dependent
ICC/IF Assay dependent
IHC-P 1:25-100
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
IHC Assay dependent
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片

预期分子量

32 kDa. ( Note )

产品属性

形式

Liquid

存储溶液

Tris, 1% BSA

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

免疫原种属

Human

纯化方式

Unpurified

偶联

Unconjugated

RRID

AB_2887573

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

相关讯息

别名

programmed cell death 1 , CD279 , PD-1 , PD1 , SLEB2 , hPD-1 , hPD-l , hSLE1

细胞定位

Membrane; Single-pass type I membrane protein

功能与背景

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

数据库

研究领域

產品图片

Anti-PD1 antibody [NAT105] used in IHC (Paraffin sections) (IHC-P). GTX20256

GTX20256 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX20256 PD1 antibody [NAT105].

文献引用

Application Reference

Li L et al. Pharmacological Research - Modern Chinese Medicine 2021; 1 A combination therapy of ingredients from TCM for the prevention and treatment of gastric cancer by targeting HER2/ PD-L1.
Zhang S et al. BMC Cancer 2020; 20 (1) : 127 PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas.
实验应用 : IHC-P
种属反应 : Human

Clone Reference

Kammerer-Jacquet SF et al. Int J Cancer 2017; 140 (1):142-148 Independent association of PD-L1 expression with noninactivated VHL clear cell renal cell carcinoma-A finding with therapeutic potential.
Bastman JJ et al. J Clin Endocrinol Metab 2016; 101 (7):2863-73 Tumor-Infiltrating T Cells and the PD-1 Checkpoint Pathway in Advanced Differentiated and Anaplastic Thyroid Cancer.
实验应用 : IHC
种属反应 : Human
Li CW et al. Nat Commun 2016; 7:12632 Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.
种属反应 : Mouse
显示更多 +
我要回报文献

产品评论

目前没有使用 PD1 antibody [NAT105] (GTX20256) 的产品评论被收录。快发表第一篇产品评论吧！
我要评论产品
Application Reference
Li L et al. Pharmacological Research - Modern Chinese Medicine 2021; 1 A combination therapy of ingredients from TCM for the prevention and treatment of gastric cancer by targeting HER2/ PD-L1.
Zhang S et al. BMC Cancer 2020; 20 (1):127 PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas.
实验应用 : IHC-P
种属反应 : Human
Clone Reference
Kammerer-Jacquet SF et al. Int J Cancer 2017; 140 (1):142-148 Independent association of PD-L1 expression with noninactivated VHL clear cell renal cell carcinoma-A finding with therapeutic potential.
Paulsen EE et al. Clin Lung Cancer 2016; Assessing PDL-1 and PD-1 in Non-Small Cell Lung Cancer: A Novel Immunoscore Approach.
实验应用 : WB, IHC-P
种属反应 : Human
Kaewkangsadan V et al. J Immunol Res 2016; 2016:4757405 Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer.
实验应用 : IHC-P
种属反应 : Human
Dronca RS et al. JCI Insight 2016; 1 (6) T cell Bim levels reflect responses to anti-PD-1 cancer therapy.
实验应用 : IHC-P
种属反应 : Human
Bastman JJ et al. J Clin Endocrinol Metab 2016; 101 (7):2863-73 Tumor-Infiltrating T Cells and the PD-1 Checkpoint Pathway in Advanced Differentiated and Anaplastic Thyroid Cancer.
实验应用 : IHC
种属反应 : Human
Li CW et al. Nat Commun 2016; 7:12632 Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.
种属反应 : Mouse
Joseph RW et al. Cancer Immunol Res 2015; 3 (1):18-22 Lichenoid dermatitis in three patients with metastatic melanoma treated with anti-PD-1 therapy.
Mishra V et al. Int J Physiol Pathophysiol Pharmacol 2015; 7 (2):87-97 Differential induction of PD-1/PD-L1 in Neuroimmune cells by drug of abuse.
Szabo K et al. Mediators Inflamm 2014; 2014:631787 The histopathology of labial salivary glands in primary Sjogren's syndrome: focusing on follicular helper T cells in the inflammatory infiltrates.
实验应用 : IHC-P
种属反应 : Human
Cogbill CH et al. Am J Clin Pathol 2014; 142 (1):88-98 Utility of CD279/PD-1 immunohistochemistry in the evaluation of benign and neoplastic T-cell-rich bone marrow infiltrates.
Verstegen RH et al. J Allergy Clin Immunol 2014; 134 (6):1346-1353.e9 Defective B-cell memory in patients with Down syndrome.
Arguello RJ et al. PLoS Negl Trop Dis 2014; 8 (8):e2989 Presence of antigen-experienced T cells with low grade of differentiation and proliferative potential in chronic Chagas disease myocarditis.
实验应用 : IHC-P
种属反应 : Human
Liarski VM et al. Sci Transl Med 2014; 6 (230):230ra46 Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue.
种属反应 : Human
Smeltzer JP et al. Clin Cancer Res 2014; 20 (11):2862-72 Pattern of CD14+ follicular dendritic cells and PD1+ T cells independently predicts time to transformation in follicular lymphoma.
Kim JR et al. PLoS One 2013; 8 (12):e82870 Tumor infiltrating PD1-positive lymphocytes and the expression of PD-L1 predict poor prognosis of soft tissue sarcomas.
实验应用 : IHC-P
种属反应 : Human
Kang MJ et al. Transl Oncol 2013; 6 (3):282-9 Tumor-infiltrating PD1-Positive Lymphocytes and FoxP3-Positive Regulatory T Cells Predict Distant Metastatic Relapse and Survival of Clear Cell Renal Cell Carcinoma.
实验应用 : IHC-P
种属反应 : Human
Sznol M et al. Clin Cancer Res 2013; 19 (5):1021-34 Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer.
Sato F et al. Leuk Res 2013; 37 (1):43302 Angioimmunoblastic T-cell lymphoma mice model.
French JD et al. J Clin Endocrinol Metab 2012; 97 (6):E934-43 Programmed death-1+ T cells and regulatory T cells are enriched in tumor-involved lymph nodes and associated with aggressive features in papillary thyroid cancer.
实验应用 : IHC-P
种属反应 : Human
Miyoshi H et al. Am J Clin Pathol 2012; 137 (6):879-89 Clinicopathologic analysis of peripheral T-cell lymphoma, follicular variant, and comparison with angioimmunoblastic T-cell lymphoma: Bcl-6 expression might affect progression between these disorders.
Bruneau J et al. Am J Pathol 2010; 177 (2):570-4 Regulatory T-cell depletion in angioimmunoblastic T-cell lymphoma.
实验应用 : IHC-Fr
种属反应 : Human
Wada N et al. Virchows Arch 2009; 455 (3):285-93 Diffuse large B-cell lymphoma with a high number of epithelioid histiocytes (lymphoepithelioid B-cell lymphoma): a study of Osaka Lymphoma Study Group.
实验应用 : IHC-P
种属反应 : Human
Roncador G et al. Haematologica 2007; 92 (8):1059-66 Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma.
SDS
Sodium Azide.pdf
产品包装 报价 (¥)
¥ 6400
联系经销商
欣博盛生物科技有限公司
欣博盛生物科技有限公司
(全国热线) 4006-800-892 / (深圳) 0755-26755892 / (北京) 010-88594029 / (上海) 021-34613729 / (广州) 18024516375 / (香港) +852-69410778
http://www.neobioscience.com
genetex@neobioscience.com