形式
Liquid
存储溶液
0.1M Tris, 0.1M Glycine, 10% Glycerol
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
0.53 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
Recombinant protein encompassing a sequence within the center region of human ITPK1. The exact sequence is proprietary.
纯化方式
Purified by antigen-affinity chromatography.
偶联
Unconjugated
RRID
AB_1950605
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
inositol-tetrakisphosphate 1-kinase , ITRPK1
功能与背景
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.
数据库
研究领域
![Anti-ITPK1 antibody [N3C3] used in Western Blot (WB). GTX107974](/upload/website/prouct_img/small/GTX107974/GTX107974_WB_w_23060120_421.webp "Anti-ITPK1 antibody [N3C3] used in Western Blot (WB). GTX107974")
![Anti-ITPK1 antibody [N3C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX107974](/upload/website/prouct_img/small/GTX107974/GTX107974_IFA_w_23060120_969.webp "Anti-ITPK1 antibody [N3C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX107974")
![Anti-ITPK1 antibody [N3C3] used in Western Blot (WB). GTX107974](/upload/website/prouct_img/normal/GTX107974/GTX107974_WB_w_23060120_421.webp "Anti-ITPK1 antibody [N3C3] used in Western Blot (WB). GTX107974")
![Anti-ITPK1 antibody [N3C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX107974](/upload/website/prouct_img/normal/GTX107974/GTX107974_IFA_w_23060120_969.webp "Anti-ITPK1 antibody [N3C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX107974")
