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BRCA2抗体 [5F6]

Anti-BRCA2 antibody [5F6] used in Western Blot (WB). GTX70123

目录号 GTX70123

文献引用 4

宿主

 Mouse

克隆

 Monoclonal

克隆编号

 5F6

同种型

 IgG1

实验应用

 WB, IHC-P, IHC-Fr

种属反应

 Human
产品包装
100 μl (¥4300)
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产品应用

应用说明

Do not boil samples for longer than two minutes. For WB: Use at a concentration of 1-5 μg/ml. Predicted molecular weight: 380 kDa. Optimal dilutions/concentrations should be determined by the reseracher.

预期分子量

384 kDa. ( Note )

产品属性

形式

Liquid

存储溶液

PBS

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

浓度

1 mg/ml (Please refer to the vial label for the specific concentration.)

免疫原种属

Human

免疫原

Amino acids 2336-2478 of human BRCA2 expressed in E. coli. BRCA2-P400.

纯化方式

Protein G purified

偶联

Unconjugated

RRID

AB_368624

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

相关讯息

别名

BRCA2 DNA repair associated , BRCC2 , BROVCA2 , FACD , FAD , FAD1 , FANCD , FANCD1 , GLM3 , PNCA2 , XRCC11

细胞定位

Nucleus

功能与背景

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]

数据库

研究领域

產品图片

Anti-BRCA2 antibody [5F6] used in Western Blot (WB). GTX70123

GTX70123 WB Image

Whole cell extract (30 μg) was separated by 5% SDS-PAGE, and the membrane was blotted with BRCA2 antibody [5F6] (GTX70123) diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

文献引用

Application Reference

Soni A et al. DNA Repair (Amst) 2021; 101 : 103076 Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses.
Bosviel R et al. OMICS 2012; 16 (5) : 235-44 Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer?
实验应用 : IHC-P
种属反应 : Human
Bernard-Gallon DJ et al. Anticancer Res 2004; 24 (1) : 321-4 Differential expressions of BRCA1 and BRCA2 in infantile gynecomastia.
实验应用 : IHC-P
种属反应 : Human
Bernard-Gallon DJ et al. Breast Cancer Res 2001; 3 (1) : 22402 BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite.
实验应用 : IHC-P
种属反应 : Human
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PBS.pdf
产品包装 报价 (¥)
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